Powder embossing method for selective loading of polymeric microcontainers with drug formulation

Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency.

Encapsulation of small-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing polymeric nanoparticles (NPs). The loadings and loading efficiencies of a wide range of drugs in polymeric NPs, however, tend to be very low. In this Communication, we report a strategy to prepare polymeric NPs with exceptionally high drug loading (>50%) and quantitati...

Ion Selective Carbon Paste Electrode For The Determination Of Flavoxate Muscle Relaxant Drug In Pharmaceutical Formulation

Abstract The utility of carbon paste electrode for the determination of flavoxate HCl modified with flavoxate-tetraphenylborate (FLX-TPB) and flavoxate-phosphotungestic acid (FLX-PTA) ion-pairs in batch mode is demonstrated. The electrodes revealed a Nernstian response over a wide concentration ranges 1.39×10-5-1x10-2 mol L-1 and1×10-5-1x10-2 mol L-1 using FLX-TPB and FLX-PTA, respectively. The...

Electrospun polymeric nanofibers for transdermal drug delivery

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

Microcontainers as an oral drug delivery system